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Fifth Inter-Institute Workshop on
Optical Diagnostic Imaging from Bench to Bedside at the National Institutes of Health
25-27 September 2006
Natcher Auditorium, National Institutes of Health
Bethesda, Maryland USA
Amir H. Gandjbakhche, National Institutes of Health
Bruce J. Tromberg, University of California, Irvine
Workshop Chairs
Abby J. Vogel, National Institutes of Health and the University of Maryland
Workshop Technical Coordinator
The program includes invited oral presentations by international experts and contributed presentations in poster format. In addition, special panels are planned on the following hot topics:
- multi-modality imaging
- development of molecular contrast agents
- women's health issues
- multi-disciplinary networks of scientists (NIH roadmap)
- European and American networks
- science-industry partnerships
- funding opportunities and prospects at NIH
Be a part of this leading technical workshop-your contribution matters.
For more information, visit: http://spie.org
Slides from Optical Imaging 2006
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Session 1: Keynote Speakers
Welcome Address, A.H. Gandjbakhche, National Institutes of Health http://videocast.nih.gov/ram/welcome.ram
Optical imaging: bringing cell biology and physiology together in vivo, R. S. Balaban, National Institutes of Health http://videocast.nih.gov/ram/01Balaban.ram
Optical Imaging in the Neurosciences, A. P. Koretsky, National Institutes of Health http://videocast.nih.gov/ram/02Koretsky.ram
The role of optical technologies in oncology, D. C. Sullivan, National Cancer Institute http://videocast.nih.gov/ram/03Sullivan.ram
Translational optical imaging research supported at the NIBIB, B. Seto, National Institutes of Health http://videocast.nih.gov/ram/04Seto.ram
Introduction of award to Brian C. Wilson for extraordinary pioneering contributions to the translation of optical technologies from blackboard to benchtop to bedside, B. J. Tromberg, University of California/Irvine http://videocast.nih.gov/ram/05BrianWilsonawardslides.ram
Detection/Treatment of Dysplasia in Barrett’s Esophagus: A Pivotal Challenge for Biophotonics, Brian C. Wilson, Professor of Medical Biophysics, Univ. of Toronto (Canada) http://videocast.nih.gov/ram/05Wilson.ram
Session 2: Molecular Imaging
The imaging probe development center: an NIH core synthesis resource for imaging probes, G. Griffiths, National Institutes of Health (Keynote Presentation) http://videocast.nih.gov/ram/06Griffiths.ram
Nanomolecules and nanoparticles in optical tumor imaging, S. Achilefu, Washington Univ. in St. Louis http://videocast.nih.gov/ram/07Achilefu.ram
Quantitative molecular imaging using time-resolved intensity and lifetime, A. H. Gandjbakhche, National Institutes of Health http://videocast.nih.gov/ram/08Gandjbakhche.ram
Activatable fluorescent optical probes for in vivo molecular imaging, P. L. Choyke, National Institutes of Health http://videocast.nih.gov/ram/09Choyke.ram
Miniaturized, disposable microscopy probes for early cancer detection, T. S. Tkaczyk, The Univ. of Arizona http://videocast.nih.gov/ram/129Tkaczyk.ram
Session 3: Translating Optical Technologies from Benchtop to Clinical Standard
Overcoming barriers to clinical translation, B. J. Tromberg, Univ. of California/Irvine http://videocast.nih.gov/ram/11tromberg.ram
Informatics platforms to support collaboration and drive standardization, J. C. Pearson, Siemens Corporate Research http://videocast.nih.gov/ram/12Pearson.ram
Optics and the pathology gold standard, J. M. Crawford, Univ. of Florida http://videocast.nih.gov/ram/13Crawford.ram
Commercial barriers and pathways, D. A. Benaron, Spectros Corp. http://videocast.nih.gov/ram/14Benaron.ram
Panel Discussion: Translating Optical Technologies from Benchtop to Clinical Standard
Chair: Bruce J. Tromberg, Univ. of California/Irvine;
Participants: John Pearson (Siemens Corporate Research), Jim Crawford (Univ. of Florida), David Benaron (Spectros Corporation), Anthony Hayward (NCRR/NIH), Ronald Waynant (FDA), Peter Barker (NIST) http://videocast.nih.gov/ram/S3PanelDiscussion.ram
Session 4: Optical Imaging: Translation to Preclinical and Clinical Applications I
OCT in cardiovascular and musculoskeletal diseases, M. E. Brezinski, Massachusetts Institute of Technology http://videocast.nih.gov/ram/15Brezinski.ram
Second harmonic generation imaging microscopy of osteogenesis imperfecta, P. J. Campagnola, Univ. of Connecticut Health Ctr. http://videocast.nih.gov/ram/16Campagnola.ram
Dynamics and resilience of blood flow in cortical microvessels revealed with optical imaging and manipulation, D. Kleinfeld, Univ. of California/ San Diego http://videocast.nih.gov/ram/17Kleinfeld.ram
Potential and challenges of high-resolution endoscopic technologies for optical biopsy of internal organs, X. Li, Univ. of Washington http://videocast.nih.gov/ram/18XingdeLi.ram
In vivo microscopy and flow cytometry: application to bone marrow cell trafficking, C. P. Lin, Massachusetts General Hospital http://videocast.nih.gov/ram/19Lin.ram
Bringing in-vitro assays to life with fluorescence molecular tomography (FMT), V. Ntziachristos, Massachusetts General Hospital http://videocast.nih.gov/ram/20Ntziachristos.ram
Session 5: Optical Imaging: Translation to Preclinical and Clinical Applications II
Confocal mosaicing of basal cell carcinomas in skin excisions to potentially guide Mohs surgery: recent advances in translational research toward surgical pathology-at-the-bedside, M. Rajadhyaksha, Y. G. Patel, K. S. Nehal, I. Aranda, Y. Li, A. C. Halpern, Memorial Sloan-Kettering Cancer Ctr. http://videocast.nih.gov/ram/21Rajadhyaksha.ram
High-resolution biophotonic imaging, L. V. Wang, Washington Univ. in St. Louis http://videocast.nih.gov/ram/22Wang.ram
Single molecule probing of dynamic conformations, molecular interactions and dynamic localizations in-vitro, in live cells and in organisms, S. Weiss, Univ. of California/Los Angeles http://videocast.nih.gov/ram/23Weiss.ram
Optical molecular imaging for early detection of cancer, R. R. Richards-Kortum, Rice Univ. http://videocast.nih.gov/ram/24Richards-kortum.ram
Session 6: Optical Coherence Tomography
In vivo coherence-based quantitative imaging from cells to tissues, J. A. Izatt, Duke Univ. http://videocast.nih.gov/ram/25zatt.ram
Fourier domain functional optical coherence tomography, Z. Chen, Univ. of California/Irvine http://videocast.nih.gov/ram/26Chen.ram
Advances in clinical ophthalmic OCT, J. S. Schuman, G. Wollstein, H. Ishikawa, L. E. Kagemann, Jr., M. Gabrielle, Univ. of Pittsburgh; M. Wojtkowski, V. J. Srinivasan, Massachusetts Institute of Technology; J. Ducker, Tufts Univ.; J. G. Fujimoto, Massachusetts Institute of Technology http://videocast.nih.gov/ram/27Schuman.ram
Contrast enhancement techniques for coherent optical imaging, S. A. Boppart, Univ. of Illinois at Urbana-Champaign http://videocast.nih.gov/ram/28Boppart.ram
Session 7: Optical Devices and Methods in Drug Discovery: Role of Industry
Optical methods in drug discovery and development (Invited Paper), M. Analoui, Pfizer Inc. http://videocast.nih.gov/ram/29analoui.ram
An optical and multimodal imaging platform for integration, post-processing, and standardization, F. S. Azar, Siemens Corporate Research http://videocast.nih.gov/ram/30Azar.ram
The evolving role of optical imaging in clinical practice -- a personal view, F. P. Jansen, GE Global Research http://videocast.nih.gov/ram/31Jansen.ram
Opportunities and challenges of imaging in translational medicine, T. Krucker, Novartis Institutes for Biomedical Research http://videocast.nih.gov/ram/32Krucker.ram
Optical imaging in oncology drug discovery, C. Sur, Merck and Co., Inc. http://videocast.nih.gov/ram/33Sur.ram
Panel Discussion: Effective Interaction Among Research Institutions and the Private Sector
Participants: Joe Schmitt, Lightlab Imaging, Ken Kaufmann, Hamamatsu, Randall Barbour, SUNY Downstate, Yiwei (Kevin) Jia, Olympus America Inc.
http://videocast.nih.gov/ram/S7PanelDiscussion.ram
Session 8: Optics in Neuroscience
Structural imaging of the Alzheimer brain with multiphoton microscopy: effects of therapeutic interventions, B. J. Bacskai, Massachusetts General Hospital http://videocast.nih.gov/ram/34Bacskai.ram
High resolution functional optical imaging of rodent cortex: investigating mechanisms of functional activation, E. M. C. Hillman, Columbia Univ. http://videocast.nih.gov/ram/35Hillman.ram
Human brain mapping with high-density diffuse optical tomography, J. P. Culver, Washington Univ. http://videocast.nih.gov/ram/36Culver.ram
Functional DOT imaging: technology, calibration and new findings, R. L. Barbour, SUNY/Downstate Medical Ctr. and NIRx Medical Technologies http://videocast.nih.gov/ram/37Barbour.ram
The role of quantitative frequency domain near-infrared spectroscopy in the NIC, E. Grant, Massachusetts General Hospital http://videocast.nih.gov/ram/38Grant.ram
Optical molecular imaging: from single molecule to human body, M. Tamura, Hokkaido Univ. (Japan) http://videocast.nih.gov/ram/39Tamura.ram
Panel Discussion: Optics in Neuroscience
Chair: Elizabeth M. C. Hillman, Columbia Univ.
Participants: Brian Bacskai, Massachusetts General Hospital; Joe Culver, Washington Univ.; Randall Barbour, SUNY Downstate; Ellen Grant, Massachusetts General Hospital; Mamoru Tamura, Hokkaido Univ. (Japan); Maria-Angela Franceschini, Massachusetts General Hospital; Yutaka Yamashita, Hamamatsu
http://videocast.nih.gov/ram/S8PanelDiscussion.ram
Session 9: New Optical Devices and Methods
Non-invasive sensing of glucose and hemoglobin, H. Primack, OrSense Ltd. (Israel) http://videocast.nih.gov/ram/40Primack.ram
Novel small animal imaging system and intravital laser scanning microscope help observing cellular to whole animal fluorescence images, Y. Kawano, N. Onda, I. Sakai, K. Kojima, Olympus Corp. (Japan) http://videocast.nih.gov/ram/41Kawano.ram
Current tools for in vivo imaging, L. Greenfield, Invitrogen http://videocast.nih.gov/ram/43Greenfield.ram
New methodology of optical blood glucose monitoring based on simulation of light propagation in the skin, Y. Yamada, Univ. of Electro-Communications (Japan); K. Maruo, Matsushita Electric Works, Ltd. (Japan); H. Arimoto, National Institute of Advanced Industrial Science and Technology (Japan); M. Tamura, Hokkaido Univ. (Japan); Y. Ozaki, Kwansei Gakuin (Japan) http://videocast.nih.gov/ram/44Yamada.ram
Quantitative monitoring and imaging using near-infrared time-resolved spectroscopy, Y. Yamashita, Hamamatsu Photonics K.K. ( Japan) http://videocast.nih.gov/ram/136Yamashita.ram
Session 10: Forum on NIH Support for Optical Imaging
Funding opportunities at the National Cancer Institute (NCI), H. R. Baker, National Cancer Institute http://videocast.nih.gov/ram/45Baker.ram
Funding opportunities at the National Institute for Biomedical Imaging and Bioengineering (NIBIB), Y. Zhang, National Institutes of Health http://videocast.nih.gov/ram/46Zhang.ram
Funding opportunities at the National Center for Research Resources (NCRR), G. Farber, National Institutes of Health http://videocast.nih.gov/ram/47Farber.ram
Funding opportunities at the National Institute of Neurological Disorders and Stroke (NINDS), Babcock, National Institutes of Health http://videocast.nih.gov/ram/48Babcock.ram
Question and Answer Session http://videocast.nih.gov/ram/Session10QA.ram
Vogel, A., A. Gandjbakhche, and I. Gannot. Demystifying Optical Diagnostics. J X-Ray Science and Technology, 14(1): 55-72 (April 2006).
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