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Enhancing diffraction-limited images using properties
of the point spread function
The algorithm developed in the Section of Biomedical Stochastic Physics enhances diffraction-limited images based on pixel-to-pixel correlations introduced by the finite width of the Point Spread Function (PSF). We simulate diffraction-limited images of point sources by convolving the PSF of a diffraction-limited lens with simulated images, and enhance the blurred images with our algorithm. Our algorithm reduces the PSF width, increases the contrast, and reveals structure on a length scale half of that resolvable in the unenhanced image. Our enhanced images compare favorably with images enhanced by conventional Tikhonov regularization.
Click here to download a zip file that includes Matlab functions to run the image enhancement algorithm, a manual that describes the algorithm and the Optics Express paper that describes the work.
Small, A., I. Ilev, V. Chernomordik, and A. Gandjbakhche. Enhancing diffraction-limited images using properties of the point spread function. Optics Express 14(8): 3193 (April 2006).
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